SACCHAROMYCES BOULARDII: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

Overview

Saccharomyces boulardii (S. boulardii) is a type of probiotic ("friendly" organism). It's a yeast that is actually a strain of Saccharomyces cerevisiae.

"Friendly" organisms such as S. boulardii can help fight off "bad" organisms that might cause diseases. S. boulardii is different from other strains of S. cerevisiae, commonly known as brewer's yeast and baker's yeast.

People commonly use S. boulardii for treating and preventing diarrhea, including rotaviral diarrhea in children. It's also used for other types of diarrhea, acne, a digestive tract infection that can lead to ulcers, and many other conditions, but there is no good scientific evidence to support many of its other uses. There is also no good evidence to support using S. boulardii for COVID-19.

Don't confuse S. boulardii with other probiotics, or with fermented food products such as fermented milk, kefir, or yogurt. These are not the same.

Uses & Effectiveness ?

Likely Effective for

  • Diarrhea. Taking S. boulardii by mouth can reduce how long diarrhea lasts in children. It's not clear if it helps children with longer-lasting diarrhea or if it helps adults.

Possibly Effective for

  • Diarrhea in people taking antibiotics (antibiotic-associated diarrhea). Taking S. boulardii by mouth can help prevent diarrhea in adults and children being treated with antibiotics.
  • Infection of the gastrointestinal tract by bacteria called Clostridioides difficile. Taking S. boulardii by mouth seems to help prevent diarrhea from C. difficile infection. Taking it along with antibiotics also seems to help prevent this infection from coming back.
  • A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). Taking S. boulardii by mouth along with standard H. pylori treatment helps prevent side effects such as diarrhea and nausea that occur with standard H. pylori treatment. But it isn't clear if taking S. boulardii helps these standard treatments to work better.
  • A serious intestinal disease in premature infants (necrotizing enterocolitis or NEC). Most research shows that giving S. boulardii by mouth to preterm infants prevents NEC.
  • Diarrhea caused by rotavirus. Taking S. boulardii by mouth seems to reduce how long diarrhea lasts in children with diarrhea caused by rotavirus.
  • Travelers' diarrhea. Taking S. boulardii by mouth seems to reduce the risk of developing diarrhea while traveling.

Possibly Ineffective for

  • Blood infection (sepsis). Giving S. boulardii to preterm infants by mouth does not prevent sepsis.

There is interest in using S. boulardii for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Special Precautions and Warnings

When taken by mouth: S. boulardii is likely safe when used for up to 15 months. It can cause gas in some people. Pregnancy and breast-feeding: There isn't enough reliable information to know if S. boulardii is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: S. boulardii is possibly safe for most children when taken by mouth appropriately. But diarrhea in children should be evaluated by a healthcare professional before using S. boulardii. There isn't enough reliable information to know if S. boulardii is safe for very small premature infants.

Elderly: Older adults might have an increased risk of fungal infection when taking S. boulardii. Stay on the safe side and avoid use.

Digestive tract disease: S. boulardii has caused fungal infections in people with diseases of the digestive tract. If you have a digestive tract disease, talk with your healthcare provider before taking S. boulardii.

Weakened immune system: S. boulardii has caused fungal infections in people with weakened immune systems. In many cases, the infection was due to a catheter becoming contaminated. If you have a weakened immune system, talk with your healthcare provider before taking S. boulardii.

Yeast allergy: People with yeast allergy can be allergic to products containing S. boulardii. Stay on the safe side and avoid these products.

Interactions ?

    Minor Interaction

    Be watchful with this combination

  • Medications for fungal infections (Antifungals) interacts with SACCHAROMYCES BOULARDII

    S. boulardii is a fungus. Medications for fungal infections help reduce fungus in and on the body. Taking S. boulardii with medications for fungal infections can reduce the effects of S. boulardii.

Dosing

In adults, S. boulardii has most often been taken by mouth in doses of 500-1000 mg (about 10-20 billion colony-forming units) daily for 4 weeks. In children, S. boulardii has most often been taken by mouth in doses of 250-500 mg (about 5-10 billion colony-forming units) for up to 4 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circ*mstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

SACCHAROMYCES BOULARDII: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

FAQs

What are the dangers of Saccharomyces boulardii? ›

In general, S. boulardii is well-tolerated, but common side effects include bloating, flatulence, and constipation. People with a weakened immune system or who have central venous catheters should not use S. boulardii due to the risk of fungal infection in the blood.

Should you take Saccharomyces boulardii every day? ›

The following doses have been studied in scientific research: BY MOUTH: For diarrhea associated with the use of antibiotics: 250-500 mg of Saccharomyces boulardii two to four times a day. For diarrhea caused by Clostridium difficile: 1 gram of Saccharomyces boulardii daily for 4 weeks along with antibiotic treatment.

What does Saccharomyces boulardii do in the body? ›

People commonly use S. boulardii for treating and preventing diarrhea, including rotaviral diarrhea in children. It's also used for other types of diarrhea, acne, a digestive tract infection that can lead to ulcers, and many other conditions, but there is no good scientific evidence to support many of its other uses.

What are the bad side effects of Florastor? ›

A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Does Saccharomyces boulardii heal leaky gut? ›

Saccharomyces Boulardii

S. boulardii, a friendly yeast, has been found to reduce antibiotic-associated diarrhoea and gastroenteritis, and helps to prevent leaky gut [Source: PubMed].

How long does it take for S. boulardii to work? ›

Yet another study from 2011 found that people with irritable bowel syndrome (IBS) who supplemented with Saccharomyces boulardii for 4 weeks experienced significant improvements in IBS-related symptoms compared to a control group.

Should you take Saccharomyces boulardii in the morning or at night? ›

Take Saccharomyces Boulardii for example; this is a strain that can be taken at any point in the day, with or without a meal and alongside antibiotics.

Does Saccharomyces boulardii flush out bad bacteria? ›

Unlike bacteria-based probiotics, S. boulardii probiotics do not permanently colonize the gut—they help restore the balance of microbiota by flushing out harmful bacteria to make room for good bacteria to flourish.

Does Saccharomyces boulardii reduce inflammation? ›

boulardii exerts a preventive effect on EHEC infection by reducing activation of NF-κB at the colonocyte level. These results, however, do not exclude the possibility that in vivo, S. boulardii can reduce mucosal inflammation by blocking NF-κB-associated pathways in immune cells of the intestinal lamina propria.

Which foods contain Saccharomyces boulardii? ›

Saccharomyces cerevisiae var. boulardii (S. boulardii) has been isolated from lychee (Litchi chinensis), mangosteen fruit, kombucha, and dairy products like kefir. Dairy products containing S.

Can you take S. boulardii with other probiotics? ›

S. Boulardii is complementary to other supplemental probiotics, and complementary to most dietary plans, including the IBD-AID.

What is another name for Saccharomyces boulardii? ›

Saccharomyces boulardii is available under the following different brand and other names: Florastor, Florastor Kids, S. boulardii, and Saccharomyces boulardii lyo.

Who should not take Saccharomyces boulardii? ›

Older adults and people with a weakened immune system: Discuss with a healthcare provider or avoid S. boulardii, as it may increase the risk of developing a fungal infection.

Is there any danger in taking probiotics? ›

Possible harmful effects of probiotics include infections, production of harmful substances by the probiotic microorganisms, and transfer of antibiotic resistance genes from probiotic microorganisms to other microorganisms in the digestive tract.

Does Florastor flush out bad bacteria? ›

Florastor works differently than bacterial-based probiotics. It flushes out bad bacteria while boosting the good bacteria to restore your natural flora and digestive balance. With 70% of the immune system residing in the digestive tract, it's important to make digestive health a priority.

Can Saccharomyces boulardii cause inflammation? ›

boulardii exerts a preventive effect on EHEC infection by reducing activation of NF-κB at the colonocyte level. These results, however, do not exclude the possibility that in vivo, S. boulardii can reduce mucosal inflammation by blocking NF-κB-associated pathways in immune cells of the intestinal lamina propria.

Is Saccharomyces harmful to humans? ›

Saccharomyces, as a genus, present low risk to human health or the environment. Criteria used to differentiate between species are based on their ability to utilize specific carbohydrates without relevance to pathogenicity.

What are the natural sources of Saccharomyces boulardii? ›

Saccharomyces cerevisiae var. boulardii (S. boulardii) has been isolated from lychee (Litchi chinensis), mangosteen fruit, kombucha, and dairy products like kefir. Dairy products containing S.

Does Saccharomyces boulardii cause weight gain? ›

Significant reductions in body weight and fat mass were also observed in obese human adults taking a 60-Day Saccharomyces boulardii -Superoxide Dismutase Supplementation (Rondanelli et al., 2021). These potential anti-obesity effects of S.

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